Tornado damage to Pfizer plant will probably create long-term shortages of some drugs hospitals need

Debris is scattered around the Pfizer facility on Wednesday in Rocky Mount, N.C., after damage from severe weather. (Travis Long/The News & Observer via AP)

The fallout from a Pfizer factory being damaged by a tornado could put even more pressure on already-strained drug supplies at U.S. hospitals, experts say.

Wednesday’s tornado touched down near Rocky Mount, North Carolina, and ripped up the roof of a Pfizer factory that makes nearly 25% of Pfizer’s sterile injectable medicines used in U.S. hospitals, according to the drugmaker.

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Pfizer said all employees were safely evacuated and accounted for, and no serious injuries were reported. The drugmaker is still assessing damage.

Here’s a closer look at the possible effects.

What are sterile injectables?

The North Carolina plant produces drugs that are injected or through an IV.

The plant makes drugs for anesthesia, medicines that treat infections and drugs needed for surgeries. The latter are used in surgeries or intensive care units for patients who are placed on ventilators, said Mike Ganio, who studies drug shortages at the American Society of Health-System Pharmacists.

The Pfizer site does not make or store the company’s COVID-19 vaccine or treatments Comirnaty and Paxlovid.

How big is the site?

There is more than 1.4 million square feet of manufacturing space, or the equivalent of more than 24 football fields, and 22 packaging lines.

How will this affect hospital drug supplies?

It will likely lead to some long-term shortages while Pfizer shifts production to other locations or rebuilds, said Erin Fox, senior pharmacy director at University of Utah Health.

The specifics of which drugs might be involved in a shortage and how long that shortage will go aren’t clear.

He noted that drugmakers tend to ship finished products quickly from manufacturing sites, which may limit how much inventory was damaged by the twister.

How can hospitals handle shortages?

They have several tools to soften the impact for patients.

Some hospitals have started increasing inventories of stored drugs instead of relying on regular deliveries from a wholesaler..

Hospitals also may switch to different forms of a drug by giving a patient an antibiotic pill instead of an IV if that person can handle it.

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